A comprehensive, systems-based National Environmental Health Risk Assessment will provide evidence on the current and future health burdens of environmental and climate change, and assess the cost-effectiveness of policies and interventions to mitigate risks and provide co-benefits in different sectors/ regions. This involves integrating epidemiologic, burden of disease, health impact, cost-benefit and equity analysis methods and indicators developed/improved by our team. Analyses include impacts of regional and sectoral interventions (e.g. health, energy, housing). Initially, we are assessing baseline/ future health and economic impacts associated with bushfires, air pollution and heat under a range of adaptation/ mitigation scenarios integrating high resolution spatiotemporal analysis methods.